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The U.S. Food and Drug Administration reviewed Contrave on December 7, and approved the drug 13-7, stating the main benefit of the drug outweighs potential risk of a possible increase in blood pressure. Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people who go through it you should err to the side of caution and allow FDA do its job and demand some research be done so that the public recognizes the side effects and hazards of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say anything to keep people on their own medications. Researchers found out that participants taking this drug for any year, dropped a few pounds within one month and have kept the load off throughout the 56 weeks of the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, that might make them more effective and safer. Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that at the time of right now there aren't any long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise blood pressure and heartrate, and shouldn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must 't be used in patients with uncontrolled high blood pressure, in addition to by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. "There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.